Home > News > Results of a multicentre, prospective, non-interventional study with a defined dry extract of Hintonia latiflora

Results of a multicentre, prospective, non-interventional study with a defined dry extract of Hintonia latiflora

Hintonia-Blaetter 300Preparations of the bark of Hintonia latiflora are used for the regulation of blood sugar homeostasis. This study was aimed on proving the dietetic value of Hintonia during dietary treatment of increased blood sugar values in patients with pre-diabetes or mild diabetes, as well as the assessment of tolerability and safety of application.


The effects of a dry concentrate of the bark of Hintonia latiflora in the form of capsules was tested in an open, prospective, muticentre non-interventional study by measuring laboratory parameters of blood sugar regulation (HbA1c, fasting and postprandial glucose) and by observing diabetic symptoms (sweating, gastrointestinal symptoms, paraesthesia, itching and neuropathies). Special attention was given to tolerability and (if given), further clinical laboratory parameters (blood pressure, liver function tests, blood lipids). An eight-month course of diabetic treatment was documented 178 study participants diagnosed with type 2 diabetes/pre-diabetes, and treated with oral antidiabetics and/or insulin.


177 data sets were available at the end of the study. HbA1c values improved in a clinically highly important and statistically significant manner, descending from 7.2  ± 0.4 % to 6.4 ± 0.4 %, corresponding to a relative improvement by 10.4 % (p < .0001). Values of fasting and post-prandial glucose improved in parallel by (in avarage) 23.3 ± 12.5 % (from 152.1 ± 27.4 mmol/l to 114.4 ± 18.2 mmol/l), and by 24.9 ± 11.4 %, respectively (from 189.5 ± 34.1 mmol/l to 140.1 ± 22.3 mmol/l). The sum score of diabetic symptoms improved from initially 4.8 points to 1.3 score points at the end of the study. Improvements were also found with blood pressure, blood lipids and liver function tests. Tolerability was excellent. There were no aderse effects, especially no hypoglycemic episodes. In 55 out of 114 patients originally using antidiabetic medication (39.5 %) the medication could be reduced (n = 45) or completely stopped (n = 10).


The study confirms the positive effects of the dry concentrate of the bark of Hintonia latiflora on the relevant parameters of blood sugar control and diabetic symptoms. In cases of pre-diabetes or mild type 2 diabetes this can contributed to effectively stabilise the blood sugar homeostasis, and thus reach a lower burden of the patient by co-medication, or to postpone the requirement for the use of oral antidiabetics and/or insulin.

Published in: Naturheilpraxis 2/2014

Dr. Mathias Schmidt and Mag. Marie Hladikova

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